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This seal consists of three tomoe, similar to the Sharingan. It is the counterpart to the Cursed Seal of Earth, and the strongest of all the cursed seals that Orochimaru uses. The seal spreads over the user's body like stains when activated.

Seireitou recieved this seal when he let Konoha and trained with Orochimaru, it was put on the right side of his neck. After about 10 years, he rebeled against Orochimaru and took over Otogakure. After Orochimaru is killed, the seal vanishes from seireitou's neck. However, when he did have it, he was able to go into both the level 1 release and the level 2 release.

Anko received her cursed seal while she was a student of Orochimaru. She, along with nine others, were the first people to receive a cursed seal. She was the only one to survive the application, establishing the one-in-ten chance of surviving the application of a cursed seal, but lacked the necessary will to use it. As such, her seal receded and Orochimaru wiped her memory. Orochimaru was able to reactivate it when they fought in the Forest of Death. Orochimaru was disappointed when he learned she lacked the malice to use the seal. Since Anko never uses her seal, her mutated form is never seen.

Sasuke also survived the application of the cursed seal. Orochimaru gives it to him against his will during the second stage of the Chunin exam. Orochimaru gave it to him as a test of the Uchiha clan's abilities, as well as a way to prepare Sasuke for becoming his next host. After Sasuke won his battle during the preliminary matches of the Chunin exam, Kakashi Hatake used the Evil Sealing Method to restrict the cursed seal, although its effectiveness is dependent on Sasuke's willpower. Regardless, Sasuke came to rely on the Heaven seal's power, thus weakening Kakashi's seal. Sasuke unlocked the Heaven seal's full power with the help of the Sound Four. When the second level of the seal is active, Sasuke's skin turns dark-gray and his hair grows much longer without losing its style. Additionally, he grows hand-shaped, beige colored wings from his back and a dark, star-shaped mark appears on the bridge of his nose. However, after Orochimaru attempted to take over Sasuke's body again during his battle with Itachi Uchiha, Orochimaru was sealed in a everlasting Genjutsu by Susanoo, removing the cursed seal from Sasuke's shoulder. It is through the extraction of Orochimaru, the seal was removed as well.

Sachi was branded with her own Curse Seal during her days at Otogakure, apparently a possible substitute for Sasuke. With help from Orochimaru, she was able to unlock its true power when she unlocked its second level. Using part of the energy used from the Five Elements Seal, she effectively "forced" the seal to synchronize with and adapt to her body, in order to nullify the detrimental effects on the body.

Kaci Wells becomes a giver of this seal and brands Seireitou Uchiha with it.

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